PhD Fellow
in Dr Malu Martinez-Chantar Lab (Liver Disease Lab) at CIC bioGUNE, Vizcaya
Dr Malu Martinez-Chantar lab is looking for a highly motivated and outstanding student to apply for the fellowship AECC postdoc in the Liver Disease lab in CIC bioGUNE
Scientific-technical training capacity of the research team
Dr Malu Martinez-Chantar is part of Ciberehd ISCIII (Centro de Investigacion Médica en Red de Enfermedades Hepáticas y Digestivas), which the main objective is to promote excellence research into liver and digestive diseases in an international context.Thus, the student will have the possibility to enroll the exchange program belong to Ciber for Liver Disease for learning new techniques, clinical approaches and translational research. Also, the involvement of the PI in the select European group of Woman in Hepatology will increase the possibilities of collaboration with internationally recognized laboratories. Finally, the network of the PI not only in the area of hepatology but also in molecular and cellular biology has been intensified through an extensive participation in different national and international networks like Hepamet Registry, MetaboCancer Excellence Network and different European COST actions PROTEOSTASIS, TRANSAUTOPHAGY and MITOEAGLE.
Based on available information and our preliminary data, we propose that impaired magnesium homeostasis is involved in determining several traits of malignancy that are characteristic of HCC, which accounts for the poor prognosis of this cancer.
The general objective of this project is to elucidate the role of the magnesium transporter "cyclin and CBS domain divalent metal cation transport mediator 1" (gene symbol CNNM1) in HCC biology and explore the usefulness of modulating magnesium content in cancer cells by pharmacological manipulation as a novel strategy to inhibit HCC development.
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