The Mechanoadaptation and Caveolae Biology Lab at CNIC, led by Prof. Miguel Angel del Pozo is recruiting a postdoctoral fellow to lead an emerging research line on mechanisms regulating tumor immunity through stromal remodeling. The selected candidate will combine state-of-the-art immunobiology and exosome biology, advanced omics and biophysics with mouse models of disease, in collaboration with top laboratories in the field (Dr. David Sancho, CNIC-Madrid, and Prof. Ignacio Melero CIMA-Navarra), to explore the cellular and molecular links between tumor stromal architecture and tumor immunomodulation. The project has recently been awarded an AECC grant (“Caveolin-1-dependent stromal remodeling: a potential novel target for cancer immunotherapy”). We welcome highly motivated candidates to apply to upcoming national (AECC, CAM, JdC) and international (AACR Immuno-oncology Research Fellowships, EMBO LTF, MSCA-IEF, HFSP) postdoctoral programs. Eligible candidates should possess a strong academic record, with first authorship of at least one Q1 publication. Previous experience preferentially in immunology, but also in extracellular matrix biology, tumor immunity, proteomics, and/or research with animal models, will be very positively valued.

Links of interest:

https://www.cnic.es/en/investigacion/mechanoadaptation-and-caveolae-biology

https://www.aecc.es/sites/default/files/content-file/24.09_PROYECTOS_AECC_2020.pdf

www.aecc.es/es/investigacion/proyectos-aecc/descubren-como-actua-molecula-fabricar-escudo-protector-tumores

https://www.youtube.com/watch?v=ZyM3C5qqTig

https://people.embo.org/profile/miguel-a-del-pozo

ORCID: https://orcid.org/0000-0001-9077-391X

ResearcherID: http://www.researcherid.com/rid/L-2861-2014

SELECTED PUBLICATIONS:

MA del Pozo, FN Lolo, A Echarri . “Caveolae: Mechanosensing and mechanotransduction devices linking membrane trafficking to mechanoadaptation”. (2021) Curr Opin Cell Biol. 2021 Feb;68:113-123. doi: 10.1016/j.ceb.2020.10.008. Epub 2020 Nov 11. PMID: 33188985 Review.

M Bosch, M Sánchez-Álvarez, […], MA del Pozo, […] Pol A. “Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense” (2020) Science. Oct 16;370(6514):eaay8085. doi: 10.1126/science.aay8085. PMID: 33060333

L Albacete-Albacete, M Sánchez-Álvarez, MA del Pozo. ”Extracellular Vesicles: An Emerging Mechanism Governing the Secretion and Biological Roles of Tenascin-C”.

L. Albacete-Albacete, […] MA del Pozo. “ECM deposition is driven by caveolin1-dependent regulation of exosomal biogenesis and cargo sorting”.(2020) J Cell Biol 219(11):e202006178. doi: 10.1083/jcb.202006178.

R. Strippoli, MA del Pozo. “Caveolin1 and YAP drive mechanically induced mesothelial to mesenchymal transition and fibrosis.” (2020) Cell Death Dis. Aug 3;11(8):647. doi: 10.1038/s41419-020-02822-1. PMID: 32811813 Free PMC article.

FN Lolo, […], MA del Pozo. “Tumor-stroma biomechanical crosstalk: a perspective on the role of caveolin-1 in tumor progression” (2020) Cancer Metastasis Rev. Jun;39(2):485-503. doi: 10.1007/s10555-020-09900-y. PMID: 32514892 Review.

A. Echarri, […] MA del Pozo. “An Abl-FBP17 mechanosensing system couples local plasma membrane curvature and stress fiber remodeling during mechanoadaptation”. (2019) Nat Commun 10, 5828

Moreno-Vicente R, […] MA del Pozo. “Caveolin-1 Modulates Mechanotransduction Responses to Substrate Stiffness through Actin-Dependent Control of YAP”. (2018) Cell Rep 25(6):1622-1635.e6

S Minguet, […] MA del Pozo. “Caveolin-1-dependent BCR nanoscale organization prevents B cell malfunction and autoimmunity”. (2017) Nat Immunol (10):1150-1159

I Navarro-Lérida, [...] MA del Pozo. “Rac1 nucleocytoplasmic shuttling drives nuclear shape changes and tumor invasion”. (2015). Dev Cell 32:318-334. # Highlighted by Dev Cell  “Previews”

R Strippoli, […] MA del Pozo. “Caveolin-1 deficiency induces a MEK-ERK1/2-Snail-1-dependent epithelial-mesenchymal transition and fibrosis during peritoneal dialysis”. (2015) EMBO Mol Med. Mar;7(3):357

RG Parton, MA del Pozo. “Caveolae as plasma membrane sensors, protectors and organizers” (2013) Nat Rev Mol Cell Biol Feb;14(2):98-112

I Navarro-Lérida, [...] MA del Pozo. “A palmitoylation switch mechanism regulates Rac1 function and membrane organization”. (2012). EMBO J 31(3):534-51.

JG Goetz, […] MA del Pozo “Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis” (2011) Cell Jul 8;146(1):148-63 

Interest send Curriculum Vitae to tamara.estevez@cnic.es

The CNIC is a center that advocates equal job opportunities for men and women, foreign and national, and promote nondiscrimination by reason of age, race or ethnic origin, religion or belief, sexual orientation, language, disability, political orientation or social or economic conditions. The CNIC ensures the utmost rigor in the application of the principles of equality, merit and ability in public employment and current rules on data protection. By participating in the selection process, the participant agrees that their data appear in the public resolutions of the selection process. Such resolutions (provisional list of admitted and excluded, definitive list of admitted and excluded and resolution of the process) are published on the CNIC website.