Contrato predoctoral asociado a proyecto
Dorso-ventral limb polarity and its implication in morphogenesis and regeneration
Referencia: PID2020-114525GB-I00
IP: Dr. Marian Ros (https://web.unican.es/ibbtec/r/MarianRosLab)
INSTITUTO DE BIOMEDICINA Y BIOTECNOLOGIA DE CANTABRIA (IBBTEC)
We search for a PhD candidate to work on this project investigating how dorso-ventral (DV) patterning is established in the developing limb. The DV organization of the limb morphology is crucial for its function yet, little is known about how it is implemented during morphogenesis. Lmx1b is the dorsal limb determinant, as it is both necessary and sufficient to specify dorsal fates that are then translated into dorsal morphologies. Our goal is to unravel Lmx1bregulation and function, which despite its relevance remain poorly defined. The research is highly multidisciplinary integrating genomic analyses, mouse genetics and in vitro and in vivo functional examination of regulatory elements.
The IBBTEC (https://web.unican.es/ibbtec/en-us/) is located in the Scientific and Technologic Park of Santander. It is well equipped with state-of-the-art research facilities supporting highly engaged groups in an enthusiastic and challenging atmosphere.
Applications: from 28.10.2021 to 11.11.202
http://www.aei.gob.es/portal/site/MICINN/menuitem.dbc68b34d11ccbd5d52ffeb801432ea0/?vgnextoid=4c6c68d98570c710VgnVCM1000001d04140aRCRD
For more information, please contact Marian Ros (rosm@unican.es)
Podrán ser solicitantes todas aquellas personas que:
- Se encuentren matriculados o admitidos en un programa de Doctorado, para el curso 2021/2022, en el momento de presentación de la solicitud o estén en disposición de estarlo en la fecha en la que se formalice el contrato.
- Que no hayan iniciado su formación predoctoral con financiación de otras ayudas destinadas a la formación predoctoral otorgada en el marco del Plan Estatal de Investigación, Desarrollo e Innovación Tecnológica o de alguno de los Planes Nacionales anteriores
- Que no hayan disfrutado de un contrato predoctoral por tiempo superior a 12 meses, previamente a la presentación de la solicitud.
- Que no sean Doctores.
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Selected publications:
- Haro E et al. (2021) Identification of limb-specific Lmx1b auto-regulatory modules with Nail-patella syndrome Pathogenicity. Nat Commun. 2021 Sep 20;12(1):5533. doi: 10.1038/s41467-021-25844-5.
- Fernandez-Guerrero et al. (2020) Mammalian-specific ectodermal enhancers control the expression of Hoxc genes in developing nails and hair follicles. Proc Natl Acad Sci U S A. 2020 Dec 1;117(48):30509-30519. doi:10.1073/pnas.2011078117.
- Fernandez-Guerrero et al. (2021) Time-sequenced transcriptomes of developing distal mouse limb buds: A comparative tissue layer analysis. Dev Dyn. 2021 Jul 12. doi: 10.1002/dvdy.394
- Bastida et al., (2020) The formation of the thumb requires direct modulation of Gli3 transcription by Hoxa13. Proc Natl Acad Sci U S A. Jan 14;117(2):1090-1096. doi: 10.1073/pnas.1919470117.
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